Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice
Identifieur interne : 001090 ( Main/Exploration ); précédent : 001089; suivant : 001091Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice
Auteurs : Chong Wang [République populaire de Chine] ; Xuexing Zheng [République populaire de Chine] ; Weiwei Gai [République populaire de Chine] ; Gary Wong [République populaire de Chine] ; Hualei Wang [République populaire de Chine] ; Hongli Jin [République populaire de Chine] ; Na Feng [République populaire de Chine] ; Yongkun Zhao [République populaire de Chine] ; Weijiao Zhang [République populaire de Chine] ; Nan Li [République populaire de Chine] ; Guoxing Zhao [République populaire de Chine] ; Junfu Li [République populaire de Chine] ; Jinghua Yan [République populaire de Chine] ; Yuwei Gao [République populaire de Chine] ; Guixue Hu [République populaire de Chine] ; Songtao Yang [République populaire de Chine] ; Xianzhu Xia [République populaire de Chine]Source :
- Antiviral Research [ 0166-3542 ] ; 2016.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques, Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Chimère, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Cytokines (immunologie), Cytokines (métabolisme), Immunité cellulaire, Immunité humorale, Infections à coronavirus (), Liaison aux protéines, Lymphocytes auxiliaires Th1 (immunologie), Lymphocytes auxiliaires Th2 (immunologie), Parvovirus canin (génétique), Protéines de capside (génétique), Protéines de capside (immunologie), Souris, Suidae, Vaccins antiviraux (administration et posologie), Vaccins antiviraux (immunologie), Vaccins à pseudo-particules virales (génétique), Vaccins à pseudo-particules virales (immunologie), Érythrocytes (virologie).
- MESH :
- administration et posologie : Vaccins antiviraux.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Parvovirus canin, Protéines de capside, Vaccins à pseudo-particules virales.
- immunologie : Cytokines, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2, Protéines de capside, Vaccins antiviraux, Vaccins à pseudo-particules virales.
- métabolisme : Cytokines.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- virologie : Érythrocytes.
- Adjuvants immunologiques, Animaux, Chimère, Immunité cellulaire, Immunité humorale, Infections à coronavirus, Liaison aux protéines, Souris, Suidae.
English descriptors
- KwdEn :
- Adjuvants, Immunologic, Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Capsid Proteins (genetics), Capsid Proteins (immunology), Chimera, Coronavirus Infections (prevention & control), Cytokines (immunology), Cytokines (metabolism), Erythrocytes (virology), Immunity, Cellular, Immunity, Humoral, Mice, Middle East Respiratory Syndrome Coronavirus (genetics), Parvovirus, Canine (genetics), Protein Binding, Swine, Th1 Cells (immunology), Th2 Cells (immunology), Vaccines, Virus-Like Particle (genetics), Vaccines, Virus-Like Particle (immunology), Viral Vaccines (administration & dosage), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Viral Vaccines.
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , genetics : Capsid Proteins, Vaccines, Virus-Like Particle.
- chemical , immunology : Capsid Proteins, Cytokines, Vaccines, Virus-Like Particle, Viral Vaccines.
- chemical , metabolism : Cytokines.
- chemical : Adjuvants, Immunologic.
- genetics : Middle East Respiratory Syndrome Coronavirus, Parvovirus, Canine.
- immunology : Th1 Cells, Th2 Cells.
- prevention & control : Coronavirus Infections.
- virology : Erythrocytes.
- Animals, Chimera, Immunity, Cellular, Immunity, Humoral, Mice, Protein Binding, Swine.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) has continued spreading since its emergence in 2012 with a mortality rate of 35.6%, and is a potential pandemic threat. Prophylactics and therapies are urgently needed to address this public health problem. We report here the efficacy of a vaccine consisting of chimeric virus-like particles (VLP) expressing the receptor binding domain (RBD) of MERS-CoV. In this study, a fusion of the canine parvovirus (CPV) VP2 structural protein gene with the RBD of MERS-CoV can self-assemble into chimeric, spherical VLP (sVLP). sVLP retained certain parvovirus characteristics, such as the ability to agglutinate pig erythrocytes, and structural morphology similar to CPV virions. Immunization with sVLP induced RBD-specific humoral and cellular immune responses in mice. sVLP-specific antisera from these animals were able to prevent pseudotyped MERS-CoV entry into susceptible cells, with neutralizing antibody titers reaching 1: 320. IFN-γ, IL-4 and IL-2 secreting cells induced by the RBD were detected in the splenocytes of vaccinated mice by ELISpot. Furthermore, mice inoculated with sVLP or an adjuvanted sVLP vaccine elicited T-helper 1 (Th1) and T-helper 2 (Th2) cell-mediated immunity. Our study demonstrates that sVLP displaying the RBD of MERS-CoV are promising prophylactic candidates against MERS-CoV in a potential outbreak situation.
Url:
DOI: 10.1016/j.antiviral.2016.12.019
PubMed: 28040513
PubMed Central: 7113847
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A61
- to stream Pmc, to step Curation: 000A61
- to stream Pmc, to step Checkpoint: 000A54
- to stream PubMed, to step Corpus: 000E28
- to stream PubMed, to step Curation: 000E28
- to stream PubMed, to step Checkpoint: 000B90
- to stream Ncbi, to step Merge: 001902
- to stream Ncbi, to step Curation: 001902
- to stream Ncbi, to step Checkpoint: 001902
- to stream Main, to step Merge: 001094
- to stream Main, to step Curation: 001090
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice</title><author><name sortKey="Wang, Chong" sort="Wang, Chong" uniqKey="Wang C" first="Chong" last="Wang">Chong Wang</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Xuexing" sort="Zheng, Xuexing" uniqKey="Zheng X" first="Xuexing" last="Zheng">Xuexing Zheng</name><affiliation wicri:level="1"><nlm:aff id="aff3">School of Public Health, Shandong University, Jinan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Public Health, Shandong University, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation></author><author><name sortKey="Gai, Weiwei" sort="Gai, Weiwei" uniqKey="Gai W" first="Weiwei" last="Gai">Weiwei Gai</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">College of Veterinary Medicine, Jilin University, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Veterinary Medicine, Jilin University, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName><orgName type="university">Université de Jilin</orgName></affiliation></author><author><name sortKey="Wong, Gary" sort="Wong, Gary" uniqKey="Wong G" first="Gary" last="Wong">Gary Wong</name><affiliation wicri:level="3"><nlm:aff id="aff5">CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Hualei" sort="Wang, Hualei" uniqKey="Wang H" first="Hualei" last="Wang">Hualei Wang</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Hongli" sort="Jin, Hongli" uniqKey="Jin H" first="Hongli" last="Jin">Hongli Jin</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Feng, Na" sort="Feng, Na" uniqKey="Feng N" first="Na" last="Feng">Na Feng</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Yongkun" sort="Zhao, Yongkun" uniqKey="Zhao Y" first="Yongkun" last="Zhao">Yongkun Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Weijiao" sort="Zhang, Weijiao" uniqKey="Zhang W" first="Weijiao" last="Zhang">Weijiao Zhang</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">College of Veterinary Medicine, Jilin University, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Veterinary Medicine, Jilin University, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName><orgName type="university">Université de Jilin</orgName></affiliation></author><author><name sortKey="Li, Nan" sort="Li, Nan" uniqKey="Li N" first="Nan" last="Li">Nan Li</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Zhao, Guoxing" sort="Zhao, Guoxing" uniqKey="Zhao G" first="Guoxing" last="Zhao">Guoxing Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Li, Junfu" sort="Li, Junfu" uniqKey="Li J" first="Junfu" last="Li">Junfu Li</name><affiliation wicri:level="3"><nlm:aff id="aff5">CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yan, Jinghua" sort="Yan, Jinghua" uniqKey="Yan J" first="Jinghua" last="Yan">Jinghua Yan</name><affiliation wicri:level="3"><nlm:aff id="aff5">CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Gao, Yuwei" sort="Gao, Yuwei" uniqKey="Gao Y" first="Yuwei" last="Gao">Yuwei Gao</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Guixue" sort="Hu, Guixue" uniqKey="Hu G" first="Guixue" last="Hu">Guixue Hu</name><affiliation wicri:level="3"><nlm:aff id="aff7">College of Animal Science and Technology, Jilin Agricultural University, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Animal Science and Technology, Jilin Agricultural University, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Yang, Songtao" sort="Yang, Songtao" uniqKey="Yang S" first="Songtao" last="Yang">Songtao Yang</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Xianzhu" sort="Xia, Xianzhu" uniqKey="Xia X" first="Xianzhu" last="Xia">Xianzhu Xia</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28040513</idno><idno type="pmc">7113847</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113847</idno><idno type="RBID">PMC:7113847</idno><idno type="doi">10.1016/j.antiviral.2016.12.019</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000A61</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A61</idno><idno type="wicri:Area/Pmc/Curation">000A61</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A61</idno><idno type="wicri:Area/Pmc/Checkpoint">000A54</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A54</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:28040513</idno><idno type="wicri:Area/PubMed/Corpus">000E28</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E28</idno><idno type="wicri:Area/PubMed/Curation">000E28</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E28</idno><idno type="wicri:Area/PubMed/Checkpoint">000B90</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B90</idno><idno type="wicri:Area/Ncbi/Merge">001902</idno><idno type="wicri:Area/Ncbi/Curation">001902</idno><idno type="wicri:Area/Ncbi/Checkpoint">001902</idno><idno type="wicri:doubleKey">0166-3542:2016:Wang C:novel:chimeric:virus</idno><idno type="wicri:Area/Main/Merge">001094</idno><idno type="wicri:Area/Main/Curation">001090</idno><idno type="wicri:Area/Main/Exploration">001090</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice</title><author><name sortKey="Wang, Chong" sort="Wang, Chong" uniqKey="Wang C" first="Chong" last="Wang">Chong Wang</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Xuexing" sort="Zheng, Xuexing" uniqKey="Zheng X" first="Xuexing" last="Zheng">Xuexing Zheng</name><affiliation wicri:level="1"><nlm:aff id="aff3">School of Public Health, Shandong University, Jinan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Public Health, Shandong University, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation></author><author><name sortKey="Gai, Weiwei" sort="Gai, Weiwei" uniqKey="Gai W" first="Weiwei" last="Gai">Weiwei Gai</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">College of Veterinary Medicine, Jilin University, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Veterinary Medicine, Jilin University, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName><orgName type="university">Université de Jilin</orgName></affiliation></author><author><name sortKey="Wong, Gary" sort="Wong, Gary" uniqKey="Wong G" first="Gary" last="Wong">Gary Wong</name><affiliation wicri:level="3"><nlm:aff id="aff5">CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Hualei" sort="Wang, Hualei" uniqKey="Wang H" first="Hualei" last="Wang">Hualei Wang</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Hongli" sort="Jin, Hongli" uniqKey="Jin H" first="Hongli" last="Jin">Hongli Jin</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Feng, Na" sort="Feng, Na" uniqKey="Feng N" first="Na" last="Feng">Na Feng</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Yongkun" sort="Zhao, Yongkun" uniqKey="Zhao Y" first="Yongkun" last="Zhao">Yongkun Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Weijiao" sort="Zhang, Weijiao" uniqKey="Zhang W" first="Weijiao" last="Zhang">Weijiao Zhang</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">College of Veterinary Medicine, Jilin University, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Veterinary Medicine, Jilin University, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName><orgName type="university">Université de Jilin</orgName></affiliation></author><author><name sortKey="Li, Nan" sort="Li, Nan" uniqKey="Li N" first="Nan" last="Li">Nan Li</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Zhao, Guoxing" sort="Zhao, Guoxing" uniqKey="Zhao G" first="Guoxing" last="Zhao">Guoxing Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Li, Junfu" sort="Li, Junfu" uniqKey="Li J" first="Junfu" last="Li">Junfu Li</name><affiliation wicri:level="3"><nlm:aff id="aff5">CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yan, Jinghua" sort="Yan, Jinghua" uniqKey="Yan J" first="Jinghua" last="Yan">Jinghua Yan</name><affiliation wicri:level="3"><nlm:aff id="aff5">CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Gao, Yuwei" sort="Gao, Yuwei" uniqKey="Gao Y" first="Yuwei" last="Gao">Yuwei Gao</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Guixue" sort="Hu, Guixue" uniqKey="Hu G" first="Guixue" last="Hu">Guixue Hu</name><affiliation wicri:level="3"><nlm:aff id="aff7">College of Animal Science and Technology, Jilin Agricultural University, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Animal Science and Technology, Jilin Agricultural University, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Yang, Songtao" sort="Yang, Songtao" uniqKey="Yang S" first="Songtao" last="Yang">Songtao Yang</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Xianzhu" sort="Xia, Xianzhu" uniqKey="Xia X" first="Xianzhu" last="Xia">Xianzhu Xia</name><affiliation wicri:level="3"><nlm:aff id="aff1">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Animals</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Viral (blood)</term><term>Capsid Proteins (genetics)</term><term>Capsid Proteins (immunology)</term><term>Chimera</term><term>Coronavirus Infections (prevention & control)</term><term>Cytokines (immunology)</term><term>Cytokines (metabolism)</term><term>Erythrocytes (virology)</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Mice</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Parvovirus, Canine (genetics)</term><term>Protein Binding</term><term>Swine</term><term>Th1 Cells (immunology)</term><term>Th2 Cells (immunology)</term><term>Vaccines, Virus-Like Particle (genetics)</term><term>Vaccines, Virus-Like Particle (immunology)</term><term>Viral Vaccines (administration & dosage)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (sang)</term><term>Chimère</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Cytokines (immunologie)</term><term>Cytokines (métabolisme)</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Infections à coronavirus ()</term><term>Liaison aux protéines</term><term>Lymphocytes auxiliaires Th1 (immunologie)</term><term>Lymphocytes auxiliaires Th2 (immunologie)</term><term>Parvovirus canin (génétique)</term><term>Protéines de capside (génétique)</term><term>Protéines de capside (immunologie)</term><term>Souris</term><term>Suidae</term><term>Vaccins antiviraux (administration et posologie)</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins à pseudo-particules virales (génétique)</term><term>Vaccins à pseudo-particules virales (immunologie)</term><term>Érythrocytes (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Capsid Proteins</term><term>Vaccines, Virus-Like Particle</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Capsid Proteins</term><term>Cytokines</term><term>Vaccines, Virus-Like Particle</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Adjuvants, Immunologic</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>Parvovirus, Canine</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Parvovirus canin</term><term>Protéines de capside</term><term>Vaccins à pseudo-particules virales</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cytokines</term><term>Lymphocytes auxiliaires Th1</term><term>Lymphocytes auxiliaires Th2</term><term>Protéines de capside</term><term>Vaccins antiviraux</term><term>Vaccins à pseudo-particules virales</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Th1 Cells</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Érythrocytes</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Erythrocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chimera</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Mice</term><term>Protein Binding</term><term>Swine</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Animaux</term><term>Chimère</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Infections à coronavirus</term><term>Liaison aux protéines</term><term>Souris</term><term>Suidae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome coronavirus (MERS-CoV) has continued spreading since its emergence in 2012 with a mortality rate of 35.6%, and is a potential pandemic threat. Prophylactics and therapies are urgently needed to address this public health problem. We report here the efficacy of a vaccine consisting of chimeric virus-like particles (VLP) expressing the receptor binding domain (RBD) of MERS-CoV. In this study, a fusion of the canine parvovirus (CPV) VP2 structural protein gene with the RBD of MERS-CoV can self-assemble into chimeric, spherical VLP (sVLP). sVLP retained certain parvovirus characteristics, such as the ability to agglutinate pig erythrocytes, and structural morphology similar to CPV virions. Immunization with sVLP induced RBD-specific humoral and cellular immune responses in mice. sVLP-specific antisera from these animals were able to prevent pseudotyped MERS-CoV entry into susceptible cells, with neutralizing antibody titers reaching 1: 320. IFN-γ, IL-4 and IL-2 secreting cells induced by the RBD were detected in the splenocytes of vaccinated mice by ELISpot. Furthermore, mice inoculated with sVLP or an adjuvanted sVLP vaccine elicited T-helper 1 (Th1) and T-helper 2 (Th2) cell-mediated immunity. Our study demonstrates that sVLP displaying the RBD of MERS-CoV are promising prophylactic candidates against MERS-CoV in a potential outbreak situation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Barcena, J" uniqKey="Barcena J">J. Barcena</name></author><author><name sortKey="Blanco, E" uniqKey="Blanco E">E. Blanco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casal, J I" uniqKey="Casal J">J.I. Casal</name></author><author><name sortKey="Rueda, P" uniqKey="Rueda P">P. Rueda</name></author><author><name sortKey="Hurtado, A" uniqKey="Hurtado A">A. Hurtado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clinical Trials Gov" uniqKey="Clinical Trials Gov">Clinical Trials.gov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, C M" uniqKey="Coleman C">C.M. Coleman</name></author><author><name sortKey="Liu, Y V" uniqKey="Liu Y">Y.V. Liu</name></author><author><name sortKey="Mu, H" uniqKey="Mu H">H. Mu</name></author><author><name sortKey="Taylor, J K" uniqKey="Taylor J">J.K. Taylor</name></author><author><name sortKey="Massare, M" uniqKey="Massare M">M. Massare</name></author><author><name sortKey="Flyer, D C" uniqKey="Flyer D">D.C. Flyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cullen, L M" uniqKey="Cullen L">L.M. Cullen</name></author><author><name sortKey="Blanco, J C" uniqKey="Blanco J">J.C. Blanco</name></author><author><name sortKey="Morrison, T G" uniqKey="Morrison T">T.G. Morrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author><author><name sortKey="Kou, Z" uniqKey="Kou Z">Z. Kou</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C. Ma</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S. Sun</name></author><author><name sortKey="Poon, V K" uniqKey="Poon V">V.K. Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Kou, Z" uniqKey="Kou Z">Z. Kou</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C. Ma</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X. Tao</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, H" uniqKey="Feng H">H. Feng</name></author><author><name sortKey="Hu, G Q" uniqKey="Hu G">G.Q. Hu</name></author><author><name sortKey="Wang, H L" uniqKey="Wang H">H.L. Wang</name></author><author><name sortKey="Liang, M" uniqKey="Liang M">M. Liang</name></author><author><name sortKey="Liang, H" uniqKey="Liang H">H. Liang</name></author><author><name sortKey="Guo, H" uniqKey="Guo H">H. Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilbert, L" uniqKey="Gilbert L">L. Gilbert</name></author><author><name sortKey="Toivola, J" uniqKey="Toivola J">J. Toivola</name></author><author><name sortKey="Lehtom Ki, E" uniqKey="Lehtom Ki E">E. Lehtomäki</name></author><author><name sortKey="Donaldson, L" uniqKey="Donaldson L">L. Donaldson</name></author><author><name sortKey="K Pyl, P" uniqKey="K Pyl P">P. Käpylä</name></author><author><name sortKey="Vuento, M" uniqKey="Vuento M">M. Vuento</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilbert, L" uniqKey="Gilbert L">L. Gilbert</name></author><author><name sortKey="Toivola, J" uniqKey="Toivola J">J. Toivola</name></author><author><name sortKey="Valilehto, O" uniqKey="Valilehto O">O. Valilehto</name></author><author><name sortKey="Saloniemi, T" uniqKey="Saloniemi T">T. Saloniemi</name></author><author><name sortKey="Cunningham, C" uniqKey="Cunningham C">C. Cunningham</name></author><author><name sortKey="White, D" uniqKey="White D">D. White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grgacic, E V" uniqKey="Grgacic E">E.V. Grgacic</name></author><author><name sortKey="Anderson, D A" uniqKey="Anderson D">D.A. Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ichinohe, T" uniqKey="Ichinohe T">T. Ichinohe</name></author><author><name sortKey="Watanabe, I" uniqKey="Watanabe I">I. Watanabe</name></author><author><name sortKey="Ito, S" uniqKey="Ito S">S. Ito</name></author><author><name sortKey="Fujii, H" uniqKey="Fujii H">H. Fujii</name></author><author><name sortKey="Moriyama, M" uniqKey="Moriyama M">M. Moriyama</name></author><author><name sortKey="Tamura, S" uniqKey="Tamura S">S. Tamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, E" uniqKey="Kim E">E. Kim</name></author><author><name sortKey="Okada, K" uniqKey="Okada K">K. Okada</name></author><author><name sortKey="Kenniston, T" uniqKey="Kenniston T">T. Kenniston</name></author><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name></author><author><name sortKey="Alhajri, M M" uniqKey="Alhajri M">M.M. AlHajri</name></author><author><name sortKey="Farag, E A" uniqKey="Farag E">E.A. Farag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lan, J" uniqKey="Lan J">J. Lan</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y. Deng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G. Lu</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author><author><name sortKey="Guo, X" uniqKey="Guo X">X. Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lan, J" uniqKey="Lan J">J. Lan</name></author><author><name sortKey="Yao, Y" uniqKey="Yao Y">Y. Yao</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y. Deng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G. Lu</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Wan, Y" uniqKey="Wan Y">Y. Wan</name></author><author><name sortKey="Liu, P" uniqKey="Liu P">P. Liu</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G. Lu</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J. Qi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lo Man, R" uniqKey="Lo Man R">R. Lo-Man</name></author><author><name sortKey="Rueda, P" uniqKey="Rueda P">P. Rueda</name></author><author><name sortKey="Sedlik, C" uniqKey="Sedlik C">C. Sedlik</name></author><author><name sortKey="Deriaud, E" uniqKey="Deriaud E">E. Deriaud</name></author><author><name sortKey="Casal, I" uniqKey="Casal I">I. Casal</name></author><author><name sortKey="Leclerc, C" uniqKey="Leclerc C">C. Leclerc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lopez De Turiso, J A" uniqKey="Lopez De Turiso J">J.A. Lopez de Turiso</name></author><author><name sortKey="Cortes, E" uniqKey="Cortes E">E. Cortes</name></author><author><name sortKey="Martinez, C" uniqKey="Martinez C">C. Martinez</name></author><author><name sortKey="Ruiz De Ybanez, R" uniqKey="Ruiz De Ybanez R">R. Ruiz de Ybanez</name></author><author><name sortKey="Simarro, I" uniqKey="Simarro I">I. Simarro</name></author><author><name sortKey="Vela, C" uniqKey="Vela C">C. Vela</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez, C" uniqKey="Martinez C">C. Martinez</name></author><author><name sortKey="Dalsgaard, K" uniqKey="Dalsgaard K">K. Dalsgaard</name></author><author><name sortKey="Lopez De Turiso, J A" uniqKey="Lopez De Turiso J">J.A. Lopez de Turiso</name></author><author><name sortKey="Cortes, E" uniqKey="Cortes E">E. Cortes</name></author><author><name sortKey="Vela, C" uniqKey="Vela C">C. Vela</name></author><author><name sortKey="Casal, J I" uniqKey="Casal J">J.I. Casal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maughan, C N" uniqKey="Maughan C">C.N. Maughan</name></author><author><name sortKey="Preston, S G" uniqKey="Preston S">S.G. Preston</name></author><author><name sortKey="Williams, G R" uniqKey="Williams G">G.R. Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyamura, K" uniqKey="Miyamura K">K. Miyamura</name></author><author><name sortKey="Kajigaya, S" uniqKey="Kajigaya S">S. Kajigaya</name></author><author><name sortKey="Momoeda, M" uniqKey="Momoeda M">M. Momoeda</name></author><author><name sortKey="Smith Gill, S J" uniqKey="Smith Gill S">S.J. Smith-Gill</name></author><author><name sortKey="Young, N S" uniqKey="Young N">N.S. Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K. Modjarrad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mou, H" uniqKey="Mou H">H. Mou</name></author><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name></author><author><name sortKey="Van Kuppeveld, F J" uniqKey="Van Kuppeveld F">F.J. van Kuppeveld</name></author><author><name sortKey="Rottier, P J" uniqKey="Rottier P">P.J. Rottier</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J. Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muthumani, K" uniqKey="Muthumani K">K. Muthumani</name></author><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name></author><author><name sortKey="Reuschel, E L" uniqKey="Reuschel E">E.L. Reuschel</name></author><author><name sortKey="Tingey, C" uniqKey="Tingey C">C. Tingey</name></author><author><name sortKey="Flingai, S" uniqKey="Flingai S">S. Flingai</name></author><author><name sortKey="Villarreal, D O" uniqKey="Villarreal D">D.O. Villarreal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okada, H" uniqKey="Okada H">H. Okada</name></author><author><name sortKey="Kalinski, P" uniqKey="Kalinski P">P. Kalinski</name></author><author><name sortKey="Ueda, R" uniqKey="Ueda R">R. Ueda</name></author><author><name sortKey="Hoji, A" uniqKey="Hoji A">A. Hoji</name></author><author><name sortKey="Kohanbash, G" uniqKey="Kohanbash G">G. Kohanbash</name></author><author><name sortKey="Donegan, T E" uniqKey="Donegan T">T.E. Donegan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perera, R A" uniqKey="Perera R">R.A. Perera</name></author><author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name></author><author><name sortKey="Gomaa, M R" uniqKey="Gomaa M">M.R. Gomaa</name></author><author><name sortKey="El Shesheny, R" uniqKey="El Shesheny R">R. El-Shesheny</name></author><author><name sortKey="Kandeil, A" uniqKey="Kandeil A">A. Kandeil</name></author><author><name sortKey="Bagato, O" uniqKey="Bagato O">O. Bagato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rahimian, S" uniqKey="Rahimian S">S. Rahimian</name></author><author><name sortKey="Fransen, M F" uniqKey="Fransen M">M.F. Fransen</name></author><author><name sortKey="Kleinovink, J W" uniqKey="Kleinovink J">J.W. Kleinovink</name></author><author><name sortKey="Christensen, J R" uniqKey="Christensen J">J.R. Christensen</name></author><author><name sortKey="Amidi, M" uniqKey="Amidi M">M. Amidi</name></author><author><name sortKey="Hennink, W E" uniqKey="Hennink W">W.E. Hennink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rueda, P" uniqKey="Rueda P">P. Rueda</name></author><author><name sortKey="Hurtado, A" uniqKey="Hurtado A">A. Hurtado</name></author><author><name sortKey="Del Barrio, M" uniqKey="Del Barrio M">M. del Barrio</name></author><author><name sortKey="Martinez Torrecuadrada, J L" uniqKey="Martinez Torrecuadrada J">J.L. Martinez-Torrecuadrada</name></author><author><name sortKey="Kamstrup, S" uniqKey="Kamstrup S">S. Kamstrup</name></author><author><name sortKey="Leclerc, C" uniqKey="Leclerc C">C. Leclerc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, M R" uniqKey="Schmidt M">M.R. Schmidt</name></author><author><name sortKey="Mcginnes Cullen, L W" uniqKey="Mcginnes Cullen L">L.W. McGinnes-Cullen</name></author><author><name sortKey="Kenward, S A" uniqKey="Kenward S">S.A. Kenward</name></author><author><name sortKey="Willems, K N" uniqKey="Willems K">K.N. Willems</name></author><author><name sortKey="Woodland, R T" uniqKey="Woodland R">R.T. Woodland</name></author><author><name sortKey="Morrison, T G" uniqKey="Morrison T">T.G. Morrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slifka, M K" uniqKey="Slifka M">M.K. Slifka</name></author><author><name sortKey="Amanna, I" uniqKey="Amanna I">I. Amanna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, F" uniqKey="Song F">F. Song</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R. Fux</name></author><author><name sortKey="Provacia, L B" uniqKey="Provacia L">L.B. Provacia</name></author><author><name sortKey="Volz, A" uniqKey="Volz A">A. Volz</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N. van Doremalen</name></author><author><name sortKey="Munster, V J" uniqKey="Munster V">V.J. Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volz, A" uniqKey="Volz A">A. Volz</name></author><author><name sortKey="Kupke, A" uniqKey="Kupke A">A. Kupke</name></author><author><name sortKey="Song, F" uniqKey="Song F">F. Song</name></author><author><name sortKey="Jany, S" uniqKey="Jany S">S. Jany</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R. Fux</name></author><author><name sortKey="Shams Eldin, H" uniqKey="Shams Eldin H">H. Shams-Eldin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W. Shi</name></author><author><name sortKey="Joyce, M G" uniqKey="Joyce M">M.G. Joyce</name></author><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K. Modjarrad</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Leung, K" uniqKey="Leung K">K. Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, C" uniqKey="Wang C">C. Wang</name></author><author><name sortKey="Zheng, X" uniqKey="Zheng X">X. Zheng</name></author><author><name sortKey="Gai, W" uniqKey="Gai W">W. Gai</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, J" uniqKey="Xu J">J. Xu</name></author><author><name sortKey="Guo, H C" uniqKey="Guo H">H.C. Guo</name></author><author><name sortKey="Wei, Y Q" uniqKey="Wei Y">Y.Q. Wei</name></author><author><name sortKey="Dong, H" uniqKey="Dong H">H. Dong</name></author><author><name sortKey="Han, S C" uniqKey="Han S">S.C. Han</name></author><author><name sortKey="Ao, D" uniqKey="Ao D">D. Ao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ye, X" uniqKey="Ye X">X. Ye</name></author><author><name sortKey="Ku, Z" uniqKey="Ku Z">Z. Ku</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J. Shi</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C. Ma</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Li, L" uniqKey="Li L">L. Li</name></author><author><name sortKey="Poon, V K" uniqKey="Poon V">V.K. Poon</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Dongbei</li><li>Jilin</li></region><settlement><li>Changchun</li><li>Pékin</li></settlement><orgName><li>Université de Jilin</li></orgName></list><tree><country name="République populaire de Chine"><region name="Jilin"><name sortKey="Wang, Chong" sort="Wang, Chong" uniqKey="Wang C" first="Chong" last="Wang">Chong Wang</name></region><name sortKey="Feng, Na" sort="Feng, Na" uniqKey="Feng N" first="Na" last="Feng">Na Feng</name><name sortKey="Feng, Na" sort="Feng, Na" uniqKey="Feng N" first="Na" last="Feng">Na Feng</name><name sortKey="Gai, Weiwei" sort="Gai, Weiwei" uniqKey="Gai W" first="Weiwei" last="Gai">Weiwei Gai</name><name sortKey="Gai, Weiwei" sort="Gai, Weiwei" uniqKey="Gai W" first="Weiwei" last="Gai">Weiwei Gai</name><name sortKey="Gao, Yuwei" sort="Gao, Yuwei" uniqKey="Gao Y" first="Yuwei" last="Gao">Yuwei Gao</name><name sortKey="Gao, Yuwei" sort="Gao, Yuwei" uniqKey="Gao Y" first="Yuwei" last="Gao">Yuwei Gao</name><name sortKey="Hu, Guixue" sort="Hu, Guixue" uniqKey="Hu G" first="Guixue" last="Hu">Guixue Hu</name><name sortKey="Jin, Hongli" sort="Jin, Hongli" uniqKey="Jin H" first="Hongli" last="Jin">Hongli Jin</name><name sortKey="Li, Junfu" sort="Li, Junfu" uniqKey="Li J" first="Junfu" last="Li">Junfu Li</name><name sortKey="Li, Nan" sort="Li, Nan" uniqKey="Li N" first="Nan" last="Li">Nan Li</name><name sortKey="Wang, Chong" sort="Wang, Chong" uniqKey="Wang C" first="Chong" last="Wang">Chong Wang</name><name sortKey="Wang, Hualei" sort="Wang, Hualei" uniqKey="Wang H" first="Hualei" last="Wang">Hualei Wang</name><name sortKey="Wang, Hualei" sort="Wang, Hualei" uniqKey="Wang H" first="Hualei" last="Wang">Hualei Wang</name><name sortKey="Wong, Gary" sort="Wong, Gary" uniqKey="Wong G" first="Gary" last="Wong">Gary Wong</name><name sortKey="Xia, Xianzhu" sort="Xia, Xianzhu" uniqKey="Xia X" first="Xianzhu" last="Xia">Xianzhu Xia</name><name sortKey="Xia, Xianzhu" sort="Xia, Xianzhu" uniqKey="Xia X" first="Xianzhu" last="Xia">Xianzhu Xia</name><name sortKey="Yan, Jinghua" sort="Yan, Jinghua" uniqKey="Yan J" first="Jinghua" last="Yan">Jinghua Yan</name><name sortKey="Yang, Songtao" sort="Yang, Songtao" uniqKey="Yang S" first="Songtao" last="Yang">Songtao Yang</name><name sortKey="Yang, Songtao" sort="Yang, Songtao" uniqKey="Yang S" first="Songtao" last="Yang">Songtao Yang</name><name sortKey="Zhang, Weijiao" sort="Zhang, Weijiao" uniqKey="Zhang W" first="Weijiao" last="Zhang">Weijiao Zhang</name><name sortKey="Zhang, Weijiao" sort="Zhang, Weijiao" uniqKey="Zhang W" first="Weijiao" last="Zhang">Weijiao Zhang</name><name sortKey="Zhao, Guoxing" sort="Zhao, Guoxing" uniqKey="Zhao G" first="Guoxing" last="Zhao">Guoxing Zhao</name><name sortKey="Zhao, Yongkun" sort="Zhao, Yongkun" uniqKey="Zhao Y" first="Yongkun" last="Zhao">Yongkun Zhao</name><name sortKey="Zhao, Yongkun" sort="Zhao, Yongkun" uniqKey="Zhao Y" first="Yongkun" last="Zhao">Yongkun Zhao</name><name sortKey="Zheng, Xuexing" sort="Zheng, Xuexing" uniqKey="Zheng X" first="Xuexing" last="Zheng">Xuexing Zheng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001090 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001090 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7113847
|texte= Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28040513" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |